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DBCO-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4) piperidine Molecular Glues for Targeted Protein

SKU 95103054950
4.7
EUR245.00 EUR293.00

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Description

Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery

Product Name CA-PEG4-amide-PEG4-Bition Synonyms biotin PEG4 Halotag Ligand PEG4 CAS Number N/A Related CAS N/A Molecular Formula C35H65ClN4O11S Molecular Weight 785

CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity

Product Name BG-Cy5 Synonyms SNAP-Cy5 CAS Number Related CAS Molecular Formula C45H51N8O2 Molecular Weight 735

DBCO-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4) piperidine Molecular Glues for Targeted ProteinSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to

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