Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB Size:100mg NCT02 is a molecular glue

NCT02 is a molecular glue cyclin K degrader

The primary aliphatic amine of the red-fluorescentSulforhodamine 101 cadaverine (Texas Red C)can be reversibly coupled to aldehydes and ketones to form a Schiff base - which can be reduced to a stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3) to form new biotinylated probes

and excellent quantum yields

Contains an E3 ligase ligand with alkyl linker and a terminal piperazine moiety

Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB Size:100mg NCT02 is a molecular glueSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine