DBCO-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Size:1mg This dye hass bright fluorescence

This dye hass bright fluorescence

Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide

The far-red emission minimizes interference from cellular autofluorescence

Product Name Azide-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP Synonyms CAS Number Related CAS Molecular Formula C56H89N9O22 Molecular Weight 1240

DBCO-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Size:1mg This dye hass bright fluorescenceSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate