MC-Val-Cit-PAB(m-PEG8)-Exatecan tamra 348 SMILES OC(=O)CCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

348 SMILES OC(=O)CCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Lenalidomide-CO-C4-alkyne Synonyms Lenalidomide-4'-CO-C4-alkyne CAS Number n/a Related CAS Molecular Formula C20H21N3O4 Molecular Weight 367

Product Name 1-[2-(piperazin-1-yl)ethyl]piperazine 4TFA Synonyms CAS Number Related CAS 19479-83-5 Molecular Formula C10H22N4 Molecular Weight 198

Product Name Thalidomide-O-acetamido-C3-azide Synonyms Thalidomide-4'-O-acetamido-C3-azide CAS Number n/a Related CAS Molecular Formula C18H18N6O6 Molecular Weight 414

MC-Val-Cit-PAB(m-PEG8)-Exatecan tamra 348 SMILES OC(=O)CCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,