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DBCO has been extensively used in copper-free click chemistry
E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin
811 Purity (HPLC) >= 95% Solubility DMSO
Product Name Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG8)-MMAE Synonyms CAS Number Related CAS Molecular Formula C94H155N13O29 Molecular Weight 1931
Propargyl-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE bc DBCO has been extensively usedSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous
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