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NRX-1532 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome
Product Name Mal-Acetyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-PNP Synonyms CAS Number Related CAS Molecular Formula C49H69N7O20 Molecular Weight 1076
Compared to tetramethylrhodamine maleimides and iodoacetamides
496 SMILES OCCOCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly Size:100mg NRX-1532 acts as molecular glueSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned
