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Product Name Lenalidomide-CO-PEG1-OH Synonyms Lenalidomide-4'-CO-PEG1-OH CAS Number n/a Related CAS Molecular Formula C16H17N3O5 Molecular Weight 331
Product Name Thalidomide-C4-OH Synonyms Thalidomide-4'-C4-OH CAS Number n/a Related CAS Molecular Formula C17H18N2O5 Molecular Weight 330
It reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT)
Product Name tert-butyl 4-(3-aminopropyl)piperazine-1-carboxylate Synonyms 1-Boc-4-(3-aminopropyl)piperazine CAS Number 373608-48-1 Related CAS Molecular Formula C12H25N3O2 Molecular Weight 243
Mal-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP coumarin Product Name Lenalidomide-CO-PEG1-OH Synonyms Lenalidomide-4'-CO-PEG1-OHSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload
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