DBCO-Hexanoyl-Val-Ala-PAB(m-PEG8)-PNP Size:50mg 613 SMILES NCCCCCCNC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 Purity (HPLC)

613 SMILES NCCCCCCNC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Pomalidomide-PEG3-propargyl Synonyms Pomalidomide-4'-PEG3-propargyl CAS Number 2138439-57-1 Related CAS Molecular Formula C22H25N3O7 Molecular Weight 443

676 SMILES CC(C)(C)OC(=O)NCCCCN1CCN(CCN2CCN(CCOCCN)CC2)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

a Mal-Propionyl-Dap(m-PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility

DBCO-Hexanoyl-Val-Ala-PAB(m-PEG8)-PNP Size:50mg 613 SMILES NCCCCCCNC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload to the linker. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine