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It binds to the VHL E3 ligase with an IC50 of 0
Product Name Pomalidomide-5'-PEG5-OH Synonyms CAS Number 2641838-56-2 Related CAS Molecular Formula C23H31N3O9 Molecular Weight 493
546 SMILES OCCOCCOCCOCCOCCOCC#CC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Carmichael
Propargyl-Acetyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg It binds to the VHLSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC
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