DBCO-Hexanoyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan deuterium including biomolecules containing azide groups

including biomolecules containing azide groups through copper catalyzed azide-alkyne cycloaddition (CuAAC)

Product Name Phthalimidinoglutarimide-C4-Br Synonyms Phthalimidinoglutarimide-4'-C4-Br CAS Number n/a Related CAS Molecular Formula C17H19BrN2O3 Molecular Weight 379

ZXH-1-161 has selective degradation activity towards GSPT1

Ispinesib is an autophagic molecular degrader

DBCO-Hexanoyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan deuterium including biomolecules containing azide groupsSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU