DOTA-C5-propanamido-maleimide aminel DCAF1-based PROTACs with activity against

DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

215 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name DOTA-C4-amine Synonyms CAS Number 753421-63-5 Related CAS Molecular Formula C20H38N6O7 Molecular Weight 474

Product Name Phthalimidinoglutarimide-C4-OH Synonyms Phthalimidinoglutarimide-4'-C4-OH CAS Number 2207541-24-8 Related CAS Molecular Formula C17H20N2O4 Molecular Weight 316

DOTA-C5-propanamido-maleimide aminel DCAF1-based PROTACs with activity againstDOTA bifucational chelator containing a thiol reactive maleimide group, an alkyl linker, and the macrocyclic chelator DOTA ( 1,4,7,10 tetraazacyclododecane 1,4,7,10 tetraacetic acid). It can be used in many different diagnostic and therapeutic applications, such as MRI contrast agents, PET and SPECT imaging agents, and radiotherapeutic agents. Product Name DOTA C5 propanamido maleimide Synonyms CAS Number n a Related CAS Molecular Formula C28H45N7O10