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Product Name MaP555-Alkyne Synonyms CAS Number n/a Related CAS Molecular Formula C30H31N5O5S Molecular Weight 573
which binds to DCAF1 with a Kd by SPR and IC50 by TR-FRET of <50 nM
making the substrate particularly useful for studying enzymes such as sirtuins (e
The strain in DBCO’s cyclooctyne ring drives the reaction forward by releasing energy when it transitions to the triazole product
Mal-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4)-Exatecan Size:25mg Product Name MaP555-Alkyne Synonyms CASSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by
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