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Proteolysis targeting chimera (PROTAC) building block
Product Name Thalidomide-O-PEG1-C2-acid Synonyms Thalidomide-4'-O-PEG1-C2-acid CAS Number n/a Related CAS Molecular Formula C18H18N2O8 Molecular Weight 390
Product Name: 6-ROX alkyne Synonyms: 6-Carboxy-X-rhodamine alkyne CAS Number: N/A Molecular Formula: C36H33N3O4 Molecular Weight: 571
124 Purity (HPLC) >= 95% Solubility DMSO
Mal-Propionyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP Size:25mg Proteolysis targeting chimera (PROTAC) buildingSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP (para
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