Azide-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4)-MMAE cyclopropene Identification of a Novel Linker

Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500

Product Name Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-MMAE Synonyms CAS Number Related CAS Molecular Formula C89H145N13O28 Molecular Weight 1845

817 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)ON2C(=O)CCC2=O)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Mal-Propionyl-PEG4-Val-Ala-PAB(m-PEG8)-MMAE Synonyms CAS Number Related CAS Molecular Formula C91H149N11O28 Molecular Weight 1845

Azide-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4)-MMAE cyclopropene Identification of a Novel LinkerSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Azide Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further