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Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in antibody–drug conjugate (ADC) development
294 Purity (HPLC) >= 95% Solubility DMSO
62 SMILES Cl
PEG3 linker enhances water solubility and provides spatial separation to minimize steric hindrance during binding interactions
Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG4)-MMAE Size:10mg Fmoc-Val-Cit-PAB-PNP is a cleavable ADCSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a
