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1038/s41586-020-2760-4
794 Purity (HPLC) >= 95% Solubility DMSO
Product Name Phthalimidinoglutarimide-5'-propargyl-PEG2-OH Synonyms CAS Number n/a Related CAS Molecular Formula C20H22N2O6 Molecular Weight 386
Product Name Thalidomide-O-acetamido-PEG4-C2-azide Synonyms Thalidomide-4'-O-acetamido-PEG4-C2-azide CAS Number 2411681-89-3 Related CAS Molecular Formula C25H32N6O10 Molecular Weight 576
Mal-Acetyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-MMAE Size:5mg 1038/s41586-020-2760-4SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate
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