DBCO-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4)-Exatecan macrophage The PNP (para-nitrophenyl) moiety serves

The PNP (para-nitrophenyl) moiety serves as an activating leaving group

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Halo-DOTA-tris(t-Bu) CAS Number 1334953-45-5  Related CAS Molecular Formula C38H72ClN5O9 Molecular Weight 778

08 SMILES CC(=O)N1CCN(CC1)C1=CC=C2C(NCCN)=NC(=NC2=C1)C1(CCCCC1)C1=CC=C(Cl)C=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

DBCO-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4)-Exatecan macrophage The PNP (para-nitrophenyl) moiety servesSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further