Mal-Propionyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg 308 SMILES OCCC#CC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

308 SMILES OCCC#CC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Lenalidomide-CO-C2-acid Synonyms Lenalidomide-4'-CO-C2-acid CAS Number 1488107-60-3 Related CAS Molecular Formula C17H17N3O6 Molecular Weight 359

S)-AHPC-CO-C8-acid Synonyms CAS Number 2172819-77-9 Related CAS Molecular Formula C32H46N4O6S Molecular Weight 614

Product Name Thalidomide-O-PEG2-OH Synonyms Thalidomide-4'-O-PEG2-OH CAS Number 2581818-54-2 Related CAS Molecular Formula C17H18N2O7 Molecular Weight 362

Mal-Propionyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg 308 SMILES OCCC#CC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,