Azide-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-PNP halide 894 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)

894 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

47 Purity (HPLC) >= 95% Solubility DMSO

Product Name DOTA-tris(t-Bu)ester-PEG2-C2-propanamido-maleimide Synonyms CAS Number n/a Related CAS Molecular Formula C41H71N7O12 Molecular Weight 854

Product Name Thalidomide-O-acetamido-PEG6-C2-acid Synonyms Thalidomide-4'-O-acetamido-PEG6-C2-acid CAS Number n/a Related CAS Molecular Formula C30H41N3O14 Molecular Weight 667

Azide-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-PNP halide 894 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload to the linker. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG,