Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Size:5mg 447 SMILES OC1=CC2=C(C=C1)C1(OC(=O)C3=CC(=CC=C13)C(=O)NCCN1C(=O)C=CC1=O)C1=CC=C(O)C=C1O2 Purity (HPLC)

447 SMILES OC1=CC2=C(C=C1)C1(OC(=O)C3=CC(=CC=C13)C(=O)NCCN1C(=O)C=CC1=O)C1=CC=C(O)C=C1O2 Purity (HPLC) 98% Shipping Conditions Room Temperature Storage Conditions Refrigerated Regulatory Statemen: For Research Use Only

Product Name Thalidomide-O-acetamido-PEG3-OH Synonyms Thalidomide-4'-O-acetamido-PEG3-OH CAS Number n/a Related CAS Molecular Formula C21H25N3O9 Molecular Weight 463

Product Name 1-[2-(piperazin-1-yl)ethyl]piperazine 4TFA Synonyms CAS Number Related CAS 19479-83-5 Molecular Formula C10H22N4 Molecular Weight 198

Product Name Pomalidomide-5'-C2-acid Synonyms CAS Number 2412056-29-0 Related CAS Molecular Formula C16H15N3O6 Molecular Weight 345

Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Size:5mg 447 SMILES OC1=CC2=C(C=C1)C1(OC(=O)C3=CC(=CC=C13)C(=O)NCCN1C(=O)C=CC1=O)C1=CC=C(O)C=C1O2 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a