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Mal-Propionyl-Beta-Ala-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:5mg a Azide-Lys(m-PEG4) moiety replaces the

SKU 15234587549
4.1
EUR445.00 EUR474.00

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Ships within 48 hours · Estimated delivery Aug 24 - Aug 29

Description

a Azide-Lys(m-PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility

Product Name Azide-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB Synonyms CAS Number Related CAS Molecular Formula C38H55N9O11 Molecular Weight 813

Product Name Propargyl-Acetyl-Gly-Gly-Phe-Gly-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C45H66N6O15 Molecular Weight 931

Product Name 4-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}butanoic acid Synonyms CAS Number 1240619-81-1 Related CAS Molecular Formula C13H24N2O4 Molecular Weight 272

Mal-Propionyl-Beta-Ala-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:5mg a Azide-Lys(m-PEG4) moiety replaces theSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker

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