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Proteolysis targeting chimera (PROTAC) building block
Compared to earlier iterations
92 SMILES Cl
HaXS8 is a synthetic chemical dimerizer designed to induce covalent and irreversible intracellular dimerization between proteins tagged with HaloTag and SNAP-tag
Mal-Propionyl-PEG2-Val-Ala-PAB(m-PEG8)-MMAE sir Proteolysis targeting chimera (PROTAC) buildingSOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly
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