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Chemical development of intracellular protein heterodimerizers
dCeMM2 (Compound 2) is a glue degrader
It is a good glutamate transglutaminase substrate and a useful building block for small fluorescent molecules
1126/sciadv
Mal-Acetyl-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB amine-amine Chemical development of intracellular proteinSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or
