DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan Cy5 Product Name DOTA-tris(t-Bu)ester-C4-azide Synonyms CAS

Product Name DOTA-tris(t-Bu)ester-C4-azide Synonyms CAS Number n/a Related CAS Molecular Formula C32H60N8O7 Molecular Weight 668

It is preferred for some complicated biological applications where reproducibility is critical since the minor positional difference between 5-isomer and 6-isomer might have biological implications

362 SMILES OCCCCC#CC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC1=C(F)C=C(I)C=C1)C1=CC(N)=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan Cy5 Product Name DOTA-tris(t-Bu)ester-C4-azide Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further